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Formula
Estimates the rate at which kidneys clear creatinine from the blood.
Worked Example
Creatinine Clearance (Cockcroft-Gault)
- Cockcroft-Gault Formula: CrCl (mL/min) = [(140 - age) × weight (kg)] / [72 × serum creatinine (mg/dL)]
- Multiply the result by 0.85 for female patients to account for lower muscle mass
- CrCl is primarily used for adjustment of drug dosages that are cleared by the kidneys
- Normal values are typically 95 to 135 mL/min for men and 85 to 125 mL/min for women
This formula is less accurate in patients with rapidly changing renal function, extremes of body size, or very low muscle mass. For clinical decisions, consider other markers or a 24-hour urine collection.
You can also calculate changes using our Anion Gap Calculator or Corrected Calcium Calculator.
Frequently Asked Questions
What is a normal creatinine clearance?
Healthy adults typically have a CrCl of 90 to 120 mL/min. Values below 60 mL/min often indicate significant kidney impairment.
Why does weight matter for CrCl?
Creatinine is a waste product from muscle metabolism. Larger individuals with more muscle mass produce more creatinine, which the formula accounts for using body weight.
Is CrCl the same as GFR?
They are related but not identical. GFR is the actual filtration rate, while CrCl is an estimate that slightly overestimates GFR because some creatinine is also secreted by the kidneys.
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