Transferrin Saturation Calculator

Normal transferrin saturation is typically 20% to 50%. Values can vary slightly between laboratories. Normal serum iron is 60 to 170 mcg/dL and normal TIBC is 250 to 370 mcg/dL.

A TSAT below 20% usually indicates iron deficiency, where there is not enough iron to fill the available transferrin. This is commonly seen in iron deficiency anemia, chronic blood loss, and inadequate dietary iron intake.

A TSAT above 45% suggests iron overload and is used as a screening threshold for hereditary hemochromatosis. Persistent elevation above 45% warrants genetic testing for HFE mutations.

TSAT measures iron currently in transit in the blood (on transferrin), while ferritin measures stored iron in tissues. Together they provide a complete picture: low TSAT + low ferritin = true iron deficiency; low TSAT + normal/high ferritin = anemia of chronic disease.

Yes. TSAT can be falsely elevated by recent iron supplementation, blood transfusions, or taking the blood sample in a non-fasting state. Serum iron has significant diurnal variation and is best measured in the morning while fasting.

No. This tool is for educational purposes only. Iron studies should be interpreted by a healthcare professional alongside complete blood count and clinical context.

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